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The splitting stage of glycolysis Fructose-1,6-BP is cleaved in the middle by a reverse aldol (aldolase) reaction The aldolase reaction ( Fig

128 Our previous data showed that central IR may significantly affect the expression of synaptic plasticity proteins, such as postsynaptic density protein-95 (PSD95), Arc, synapsin1, BDNF, resulting in the impaired synaptic plasticity of neurons and decreased learning and memory ability (data not shown)

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Unfortunately, even when a persons diet is rich in B12 or if they take a daily supplement, they may still be lacking, as vitamin B12 can be difficult to absorb orally