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The existence of this correlation is supported by preclinical studies in mouse xenograft models, which showed that the therapeutic inhibition of angiogenesis reduces tumor vascularization and causes hypoxia, and therefore may promote c-Met-mediated invasion of malignant cells [50]
Knowing how to distinguish between common side effects and more serious issues is a key part of using the therapy safely
Pharmacokinetic and Pharmacodynamic Evaluation : Assessing absorption, distribution, half-life, and exposureresponse relationships for long-acting peptide analogues, including the effects of lipidation and albumin binding
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