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Low levels of glutathione can impair immune function, increasing the risk of infections and autoimmune diseases

The in vivo relevance of necroptosis, NETs, and the alternative complement pathway, specifically the C5a-C5a receptor interaction, for disease induction was established in murine MPO-AAV models (135, 153155)

An example week at the 2.5 mg initiation step: The documented protocol allows the injection day to be moved if needed as long as doses stay at least several days apart, but for research clarity a fixed weekday is cleanest

All experiments were approved by the Institutional Animal Care and Use Committee at the Albert Einstein College of Medicine (Protocol #20140107)