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The term nutraceutical was coined by DeFelice in 1989 from the words nutrition and pharmaceutical and is defined as a food or part of a food that provides medical or health benefits, including the prevention and treatment of a disease

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Using this therapy as a tool to treat PAD in patients without diabetes may be a game-changer in terms of reducing morbidity and mortality. Prospective controlled clinical trials are warranted to examine the current impact of GLP-1RA on non-diabetic PAD patients