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In the context of cancer, one should not only focus on the reduction of the known carcinogens contained in cigarette smoke, but also ascertain that the emission of free radicals (including ROS and RNS) is reduced [35]

Ethics statement The studies involving humans were approved by the School of Medicine, Dentistry and Biomedical Sciences Ethics Committee at Queens University Belfast and the Research Ethics Committee at University of los Andes

It issued a new rule that declared all tobacco-related goods, including vaping products, fall under the same regulatory framework as cigarettes