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Although most drugs are metabolized by the liver, some nephrotoxicants are known to be dependent on kidney metabolism as this organ also expresses Phase I (CYPs) and Phase II (GSTs) enzymes (Anders 1980)

Ruperto N, Murray KJ, Gerloni V, Wulffraat N, De Oliveira SKF, Falcini F, Dolezalova P, Alessio M, Burgos-Vargas R, Corona F, Vesely R, Foster H, Davidson J, Zulian F, Asplin L, Baildam E, Consuegra JG, Ozdogan H, Saurenmann R, Joos R, Pistorio A, Woo P, Martini A (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate

Extensively studied in preclinical tissue models Well-characterized amino acid sequence High stability across a range of pH conditions Documented in over 100 published research papers For laboratory research use only