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Albiglutide Harmony outcomes was a double-blind trial that included a total of 9,463 T2D participants of 40 years of age and a history of CVD, who were allocated to an albiglutide (3050 mg weekly) group or placebo group ( Renoprotection of GLP-1RAs is Largely Dependent on Reduction of Albuminuria As described above, GLP-1RAs have no clinically important effect on eGFR and hard renal endpoints

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Bowel mucosa, and integrity of the intestinal epithelial barrier, is protected by IL-17, 57 meaning its removal will eventually disrupt this barrier leading to further penetration of bacteria and worsening of inflammation

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