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Statistics and reproducibility Statistical significance was determined using independent t -test for immunohistochemical and western blot analyses, and one-way analysis of variance for cell cycle and apoptosis detection by GraphPad Prism 7.0 software (GraphPad, Inc., La Jolla, CA, USA)

Niclosamide, marketed as Yomesan by Bayer (3) and other generics, has been routinely given to humans for the past 60 years as oral tablets in a 2-gram dose to cure cestode parasites (tape worms) (4)

The collagen timeline reflects findings from the Frontiers in Nutrition 2025 trial, where 180 days of supplementation produced statistically significant WOMAC improvements

Semaglutide is a glucagon-like peptide-1 (GLP-1) analog that was initially approved in 2020 as a treatment method for improving glycemic control in patients with Type 2 diabetes