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In a rat Achilles tendon transection model, BPC-157 improved tendon healing, including functional recovery, biomechanical strength, collagen formation, fibroblast activity, and microscopic tendon organization

We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs

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This is a high response rate, especially considering these patients had already failed standard treatments