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For this reason, patients with a history of immunoglobulin (Ig) Emediated (allergic or anaphylactic) reaction to a sulfonamide antibiotic can receive nonantimicrobial sulfonamides such as celecoxib, chlorthiazide, furosemide and others without elevated risk of an IgE-mediated reaction compared with the general population

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After completing a 14-day cycle, a break of one to three weeks is recommended before any repeat application [20]

If rash, burning, tingling, or inflammation occur, immediately remove the product from skin and discontinue all further use