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The transition period is called perimenopause and is when women notice changes in their monthly cycles and other symptoms, such as: Irregular periods that may skip months Lighter or heavier periods Hot flashes or night sweats Difficulty sleeping (insomnia) Mood swings and irritability Difficulty concentrating Vaginal dryness and painful sex Decreased libido The average age of menopause in the United States is 51, with most women reaching this stage between 45-58 years

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Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M, et al

The Critical Role of Slow Dose Escalation in Tolerability The single most effective strategy for reducing semaglutide side effects is gradual dose titration