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Forty RCTs that aligned with the PICO-SD criteria were selected from the systematic review,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55 and two more RCTs were added after an updated search.56, 57 The participants of these studies included general adult smokers (n = 23), patients with psychiatric conditions (n = 5), patients with pulmonary disease (n = 3), cardiovascular disease (n = 2), and other populations (n = 9)

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At this point, the returns on public-health messaging and social stigma might be bottoming out