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Treating low appetite in advanced cirrhosis should focus on addressing risk factors (such as active alcohol use, uncontrolled diabetes, and hypothyroidism), triggers (including hepatic encephalopathy, infections, electrolyte imbalances, and excessive medication burden), and related issues (such as removing symptomatic ascites, providing clear dietary recommendations, avoiding overly restrictive diets, and addressing mental health concerns) (13, 18)

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The most compelling research endpoints involve mortality and disease incidence tracked over years, as demonstrated in the long-term follow-up studies showing reduced mortality in treated groups

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