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In a transgenic model of AD, SAMe administration reversed DNA hypomethylation, including at the BACE1 promoter (51), leading to decreased A accumulation and cognitive improvements
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Studies from mouse models have revealed that the transcriptional profile of the rod-shaped microglia was akin to that of DAM (Matsuba et al., 2025) and that rod-shaped microglia interact with neuronal dendrites, attenuate motor cortical hyperactivity during an early stage of TDP-43-associated neurodegeneration (Xie et al., 2025)
[DOI] [PubMed] [Google Scholar] 49.Katoh M., Mizutani N., Keino H., Kashiwamata S
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