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It is characterized by memory loss, language difficulty, impaired judgment, mood swings and, in advanced stages, loss of self-care ability (1)

Chronic stress and trauma: The ongoing demands of midlifecareer pressures, caregiving, aging parents, and unresolved traumacan lead to persistent cortisol elevation, which has been consistently linked to immune dysregulation and increased inflammation

The second hexa-histadine tag of the protein was not utilized in these experiments, but is relevant and must be noted because Ni-NTA was used to purify the GST-GFP for several of the experiments being discussed