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A nationwide Danish retrospective cohort study indicated that GLP-1 RAs may offer protection against lower extremity amputations in patients with T2DM, compared to sulfonylureas [98]

Moreover, melatonin is also a ligand for nuclear receptors, such as retinoid orphan receptors (or retinoid Z receptors), ROR/RZR, and ROR/RZR 28,29,30 (Fig

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