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Collectively, these findings have provided broad support for the development, use, and safety of GLP-1 therapeutics in human subjects with diabetes and obesity, and have identified new disease areas (NASH, CNS disorders such as Parkinsons and Alzheimers disease) that may benefit from therapy with GLP-1R agonists

Additionally, rapid weight loss in general can promote breakdown of both fat and muscle unless muscle is actively preserved through nutrition and resistance training

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Eligible study subjects were restricted to patients diagnosed with type 2 diabetes and opioid use disorder, and who were prescribed semaglutide or other diabetes medications