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Spots or dots are rarely removed by brushing and may indicate inflammation

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"Studies suggest, however, that states with high excise taxes are more likely to have high cigarette smuggling rates." Minnesota has fueled a highly lucrative black market in tobacco products simply by raising taxes high enough to make it extremely profitable for small entrepreneurs and big criminal networks alike to smuggle in smokes from places where tobacco can be purchased more cheaply

However, in vivo findings to support this hypothesis are still lacking