Increased Risk of Colonic Complications: Although the research is still emerging, some healthcare providers believe the digestive changes caused by semaglutide may increase the risk of certain complications, especially in those already susceptible to gastrointestinal conditions like Crohns disease or irritable bowel syndrome
The label also warns about potential acute gallbladder disease and notes that tirzepatide may reduce the absorption of oral medications due to delayed gastric emptying, including oral contraceptives, which may require backup contraception for 4 weeks after initiation and after each dose increase
In obese older individuals, combining CIT with a 12-week HIIT program produced greater benefits than HIIT alone, including larger increases in handgrip and quadriceps strength, reductions in fat mass, and favorable shifts in adipose gene expression linked to lipid metabolism
Many patients report sustained appetite control, improved energy levels, and psychological victories that reinforce healthy eating patterns
