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Omega-3 fatty acids (EPA and DHA) are incorporated into cell membrane phospholipids, where they influence membrane stability. When mast cell membranes are enriched with omega-3 fatty acids, stability is supported and and they are less prone to inappropriate activation. Additional Triggers: Temperature extremes Physical exertion and exercise Infections Environmental toxins and chemicals Certain medications Alcohol (particularly red wine and beer) Food additives and preservatives Hormonal fluctuations (especially high estrogen) Magnesium deficiency Why Your Spring Symptoms Are Actually a Histamine Breakdown Problem Even after addressing mast cell activation, you still need efficient histamine clearance