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Second, we estimated multivariable linear regression models of cigarettes smoked per day, conditional on the frequency of vaping (categorized as every-day, some-days, ever but no longer, never), psychological distress (categorized as NPD, MPD, and SPD), the interaction of vaping and psychological distress (these variables were demeaned, or centered so that main effect coefficients could be directly interpreted 26 ), and other covariates described above

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Common concentrations for average users vary from 3 mg/ml to 15 mg/ml, while heavy smokers might use liquids up to 24 mg/ml