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Besides the initiation of lipid peroxidation at the cell surface, homocysteine auto-oxidation with trace metal ions, generating reactive oxygen species such as superoxide anion, hydrogen peroxide, hydroxyl, and thiol free radicals (Munday, 1989

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Biomolecules & Therapeutics, 22, 136142

The method, known as the R2KD assay, was used to characterise binding of NMR fragment screen hit 27 to TRF1 TRFH and revealed a K D value of 280 M (95% confidence intervals (CI): 230350 M, Fig