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AOP Development Strategy Context Used to provide background information for AOP reviewers and users that is considered helpful in understanding the biology underlying the AOP and the motivation for its development.The background should NOT provide an overview of the AOP, its KEs or KERs, which are captured in more detail below

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To start with, in the process of ferroptosis, Hmox1 is activated, which promotes the increase of LIP and destroys cell homeostatic capacity, thus compromising the integrity of cardiomyocytes (Kakhlon and Cabantchik 2002)

It doesnt force anything unnatural