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Patients with established cirrhosis require specialized hepatology evaluation before initiation, as safety data in advanced liver disease remain limited

No published research characterizes adverse events at sustained injectable doses above 5-10 mg/week in humans

It mimics only GLP-1, activating receptors in the pancreas, brain, and gut to reduce appetite, improve insulin sensitivity, and slow gastric emptying

In addition, testosterone deprivation downregulates the protein levels of MFN2 and OPA1 in obese rats, and mRNA levels of Opa1 and Mfn2 in the tibialis anterior muscle of mice, as well as upregulates DRP1 expression levels (108)