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Neuroinflammation in turn, interferes with neuroplasticity by reducing neurogenesis, altering synaptic architecture, and dysregulating neurotransmitter systems [7,8], changes that are closely linked to mood disturbance, cognitive impairment, and affective lability in individuals with IR [4,6,9]

In December 2025, fans worried if Sharon Osbourne was back on Ozempic In 2023, Sharon said she had stopped taking Ozempic after it made her drop 42 pounds and she feared for her health

Behav Neurosci 120:211216 Pierce K, Haist F, Sedaghat F, Courchesne E (2004) The brain response to personally familiar faces in autism: findings of fusiform activity and beyond

Constipation occurs in about 1724% of patients taking GLP-1 receptor agonists and can become uncomfortable enough that some people stop taking the medication