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The aim of gradually increasing the dose at the beginning of the treatment is to prevent side effects like nausea

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Subsequent regression analyses further explore these associations, controlling for potential confounders to identify independent determinants of tobacco use

At present, the key issue is not simply whether smoking changes OA risk, but how cigarette and EC exposure may influence the synovial-cartilage microenvironment and potentially contribute to more inflammatory or fast-progressing OA phenotypes