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Typically, the concentration of carnitine in plasma is in the low M range (~4060), while tissue concentrations (taken here to approximate cytoplasmic concentrations) are in the low mM range (~15 mM) 26,27

The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]

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Who should consider tirzepatide with B12 and who should avoid it Ideal candidates for tirzepatide with B12 include adults with obesity (BMI 30) or overweight with comorbidities (BMI 27 with conditions like type 2 diabetes, hypertension, or dyslipidemia)